Chronic kidney disease (CKD) has a high mortality rate once it reaches the most severe stage. However, complications can be reduced and even prevented if it is diagnosed and treated earlier. Many people who develop CKD become symptomatic only when the disease is well established. By that point, the opportunity for some of the interventions aimed at minimising the impact of the disease has passed. Nurses working in general practice are well placed to recognise people at risk for CKD, diagnose them early and ensure that treatment is initiated and optimised to protect their renal and cardiovascular health.